Studies on Mice Give Insight into SYNGAP1 Gene Behavior

  • In wild-type mice, the distribution of neuron activity changed: highly active cells significantly lowered or suppressed their responses, moderately active cells had little change, and weakly active cells increased their responses.
  • In SYNGAP1 mice, highly active cells developed very little and moderately active cells remained stable. But the weakly active cells did not increase their signal after the new experiment.‍
  • SYNGAP1 mice are designed so that the SYNGAP1 gene can be repaired in adulthood. After repair, they have synaptic activity similar to that of wild-type mice. This suggests that the potential window of time for treating people with SYNGAP1 mutations extends beyond early development. (i.e. in adults).

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